| Targeted Therapies: A New Generation of Cancer Treatments
These drugs are now a component of therapy for many common malignancies, including breast, colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma. The mechanisms of action and toxicities of targeted therapies differ from those of traditional cytotoxic chemotherapy. Targeted therapies are generally better tolerated than traditional chemotherapy, but they are associated with several adverse effects, such as acneiform rash, cardiac dysfunction, thrombosis, hypertension, and proteinuria. Small molecule inhibitors are metabolized by cytochrome P450 enzymes and are subject to multiple drug interactions. Targeted therapy has raised new questions about the tailoring of cancer treatment to an individual patient's tumor, the assessment of drug effectiveness and toxicity, and the economics of cancer care.
Monmouth freeholders give Roe $120G consulting contract
FREEHOLD — The Monmouth County freeholders tonight approved spending $210,000 over the next year for two transportation consulting contracts, giving one of the contracts to Robert A. Roe, the embattled former congressman. Roe, 83, who did not attend the meeting, has been under fire from Mothers Against Drunk Driving, which campaigned to block a recent push to name a northern New Jersey roadway after him. The former lawmaker was convicted of driving drunk when he crashed into a minivan in Rockaway Township in 1993, seriously injuring a woman and her 15-year-old daughter.
Gov. Corzine issued a statement today saying he received a letter from Roe in which Roe "deeply regrets his responsibility for a tragic automobile accident 15 years ago. As such, he has asked that the recognition passed by the Legislature and signed into law -- the renaming of a section of Route 23 in his honor -- be rescinded.''
The Monmouth freeholders did not address the events of Roe's accident or the highway issue.
Stories by Fred Dreier
Santa Barbara, California's Adam Duvendeck turned heads with his eighth-place finish in the men's sprint at the Los Angeles round of the World Cup, held January 17-20 in Carson City, California. The result stood as the top finish by an American male sprinter throughout the ... .
Fortified Water Ads Flood Super Bowl
(Rochester, N.Y.) – The Super Bowl was awash with commercials for enhanced or "fortified" water.Are these beverages good for you, or are their claims all wet?At the Midtown Athletic Club cafe, the Vitaminwater brand is a big seller.“It tastes good and supposedly it's good for you," said Elvio Fernandez.“I have to force myself to drink water so it's a good alternative," said Jay Surgoine.The beverages come in many flavors with different vitamin and mineral combinations. Vitaminwater's Kiwi-Strawberry Focus favor has Vitamins A, C, B3, B6, B12, B5. Some of the drinks have calcium or potassium.In one ad shown during the 2008 Super Bowl, Shaquille O'Neal rides a horse to victory, thanks to Vitaminwater. In another, lizards got down to Michael Jackson while claiming the SoBe Life water brand is “thrillicious."USA Today cites figures showing that sales of fortified ("enhanced") water went up 32 percent in the first nine months of 2007.“It's definitely hype," said Rochester Institute of Technology Assistant Professor Liz Kmiecinski, who teaches a class on sports nutrition.She says the vitamins in these drinks are “totally random," and most people typically don't need a boost of the vitamins offered.“We need to get our vitamins from food, fruits and vegetables, whole grains, whole foods, dairy products, those kinds of things," Kmiecinski said.Midtown's fitness director warns clients that the water is "enhanced" with more than just vitamins.“Regular water is always better because of the calorie content, the calories.
Women's Hoops Notes: Bryant coach Burke has come a long way from Toll ...
Not quite a typical Saturday for Mary Burke, women's basketball coach at Bryant University and one of 14 men and women who will be inducted into the Providence College Athletic Hall of Fame. "When I got the letter, I couldn't believe it," Burke said. "Then I checked the schedule. Am I home or away? We play a lot of away games in New England, but am I in Albany or Syracuse?" Seeing she would be home, she relaxed, but only a little. Her game starts 30 minutes before the PC-Louisville men's game, and when the other inductees are introduced at halftime, she will still be working. "I won't be there for that, but there's a dinner at night, and I'll be OK for that," she said. Burke has come a long way since her high school days as a basketball and volleyball star at Toll Gate in Warwick.
'Unbelievable' support for radio's Fram
Radio can be one weird racket. That's why we were appreciative Thursday when Leslie Fram called us to discuss her unexpected departure from the 99X airwaves. Cumulus Media, the owner of 99X, has announced upcoming changes in content and a frequency alteration. On Thursday, Fram told us that Cumulus chose not to renew her contract "in its current state." The veteran Atlanta program director and morning show co-host told Buzz she remains under contract to Cumulus through the end of March and is due to have a meeting with station execs to discuss a possible future role with the company. Now off the air, Fram says she's grateful to longtime listeners who have reached out to her about her 17 years on the air in Atlanta. Fellow female broadcasters Vikki Locke and Mara Davis sent her flowers and well wishes, while concert promoter Peter Conlon phoned to thank her and to reminisce about the many concerts the two have helped bring to the city.
Novo Nordisk Changing Diabetes(R) Bus World Tour Rolls Into the Big ...
PRINCETON, N.J., Nov. 13 /PRNewswire-FirstCall/ -- The Changing Diabetes(R) Bus and Village will host visitors today at New York City's Union Square Park, as its tour around the globe concludes on the eve of the first United Nations-sanctioned World Diabetes Day. Novo Nordisk, the sponsor of the tour, invites visitors to Union Square Park to participate in the global drive to raise awareness about diabetes prevention and control, and encourage New Yorkers to change the future of diabetes today. Admission to the Novo Nordisk Changing Diabetes(R) Bus event is free and open to the public today from 11am to 7pm in Union Square's North Plaza. Basketball Hall of Famer and diabetes advocate, Dominique Wilkins of the Atlanta Hawks, is an ambassador for the campaign. Diagnosed with type 2 diabetes in 2000, 'Nique has been sharing his personal story in order to motivate and educate the public about this disease.
Hard winter for honeybees
Sonoma County beekeepers are reporting significant losses among their honeybees this winter including what some describe as cases of Colony Collapse Disorder, the mysterious scourge that has wiped out thousands of colonies around the nation.
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human nature
You've got a big heart," he assures the boy with a smile. That's the implicit message of Big Love. It's hard to sustain a polygamous household. It's not for everybody. Most of us are too jealous. But some people aren't, the show suggests. And for them, maybe we should tolerate or legalize plural marriage. So, let's look at how this on-air experiment is going. Talented writers and actors are trying to make plausible the idea that American women raised in an age of sexual egalitarianism are bighearted enough to share a husband. Is it working? .
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